2-Phenylpiperazine → (RS)-1-cyclopropyl-3-ethoxycarbonyl-7,9-difluoro-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine

HRID 194695

Reaction equation

HRID 194695 reaction equation
[CH:1]1([n:4]2[cH:5][c:6]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[c:7](=[O:21])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[c:14]([F:20])[c:15]([F:19])[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1.[c:27]1([CH:33]2[NH:34][CH2:35][CH2:36][NH:37][CH2:38]2)[cH:28][cH:29][cH:30][cH:31][cH:32]1>>[CH:1]1([n:4]2[cH:5][c:6]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[c:7](=[O:21])[c:8]3[cH:9][c:10]4[c:11]([n:12][c:13]23)[c:14]([F:20])[c:15]([N:37]2[CH2:36][CH2:35][NH:34][CH:33]([c:27]3[cH:28][cH:29][cH:30][cH:31][cH:32]3)[CH2:38]2)[c:16]([F:18])[cH:17]4)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 2506732-PhenylpiperazineHCID 185491641-Cyclopropyl-3-ethoxycarbonyl-7,8,9-trifluoro-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 54476705(RS)-1-cyclopropyl-3-ethoxycarbonyl-7,9-difluoro-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine

Sources & evidence

ORD record
ord-34e73f54a2c34ca1a6e6af6972d6cc9c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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