3-Fluorobenzyl bromide → 5-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-one

HRID 1948195Notes

Reaction equation

HRID 1948195 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.[F:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13]Br>>[F:9][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13][N:6]1[CH:7]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]1=[O:8]

Participants

3

Reactant 2

HCID 680073-Fluorobenzyl bromideHCID 5995285-Bromo-2-hydroxypyridine

Product 1

HCID 606276535-Bromo-1-(3-fluorobenzyl)pyridin-2(1H)-oneYield 62%

Procedure

According to Scheme 1 Step 2: 1-(3-Fluorobenzyl)-5-bromopyridin-2(1H)-one was prepared from 5-bromopyridin-2(1H)-one (Example 1 Step 1) and 3-fluorobenzyl bromide according to the procedure described for Example 2 Step 1. The crude product washed with pentane/Et2O 50/50 to afford 1-(3-fluorobenzyl)-5-bromopyridin-2(1H)-one (10.7 mmol, 3.00 g, 62%) as a white solid.

Workup

  1. washThe crude product washed with pentane/Et2O 50/50

Sources & evidence

ORD record
ord-0392181931214d6895b9cc6ab62bf4a2
Source dataset
uspto-grants-2013_03
Patent number
US08399493B2

Reaction notes

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