HCID 58277310, compound → HCID 58277288, compound

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)[N:12]=[C:11]([C:21]([O:23]CC)=[O:22])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(N2C(C3C=CC(F)=C(C(F)(F)F)C=3)=CC(C(O)=O)=N2)C=CC=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:9]2[N:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=3)[N:12]=[C:11]([C:21]([OH:23])=[O:22])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 58277310HCID 58277310, compound

HCID 58277417HCID 58277417, compound

Product 1

HCID 58277288HCID 58277288, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 34A in analogy to the synthesis of the compound of Example 77A. 3.30 g (98% of theory) of the title compound are obtained.

Sources & evidence

ORD record: ord-84cf0968efae47198ca746aca0f03795
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399682B2

Reaction notes

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