HCID 58277326, compound → HCID 58277424, compound

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=3)=[CH:12][C:11]([C:22]([O:24]CC)=[O:23])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8].ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C(O)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=3)=[CH:12][C:11]([C:22]([OH:24])=[O:23])=[N:10]2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 58277326HCID 58277326, compound

HCID 58277462HCID 58277462, compound

Product 1

HCID 58277424HCID 58277424, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 53A in analogy to the synthesis of the compound of Example 71A. 515 mg (93% of theory) of the title compound are obtained.

Sources & evidence

ORD record: ord-b49f93aad88345b38ae72ce5e19db5c9
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399682B2

Reaction notes

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