Aic-292 → HCID 58277420, compound

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)=[CH:11][C:10]([C:20]([OH:22])=O)=[N:9]2)=[CH:4][CH:3]=1.ClC1C=C(N2C(C3C=C(F)C=C(Cl)C=3)=CC(C([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=O)=N2)C=CC=1F>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=3)=[CH:11][C:10]([C:20]([N:46]3[CH2:50][C:49](=[O:51])[NH:48][CH2:47]3)=[O:22])=[N:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 44230181Aic-292

HCID 58277349HCID 58277349, compound

Product 1

HCID 58277420HCID 58277420, compound

Procedure

The preparation of the title compound takes place starting from the compound of Example 105A in analogy to the synthesis of the compound of Example 1. 15 mg (39% of theory) of the title compound are obtained.

Sources & evidence

ORD record: ord-5b73096cb6cc4b8887022f90734bdf8b
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399682B2

Reaction notes

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