3-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester → 3-[(1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

HRID 1949480Notes

Reaction equation

HRID 1949480 reaction equation
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:12][N:11]([C:13]2[S:14][CH2:15][C:16](=[O:18])[N:17]=2)[CH2:10]1)=[O:8].[F:20][C:21]([F:45])([F:44])[C:22]1[CH:39]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:37]=[CH:36][C:23]=1[CH2:24][N:25]1[C:33]2[C:28](=[CH:29][C:30]([CH:34]=O)=[CH:31][CH:32]=2)[CH:27]=[N:26]1>>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:10][N:11]([C:13]2[S:14][C:15](=[CH:34][C:30]3[CH:29]=[C:28]4[C:33](=[CH:32][CH:31]=3)[N:25]([CH2:24][C:23]3[CH:36]=[CH:37][C:38]([C:40]([F:43])([F:42])[F:41])=[CH:39][C:22]=3[C:21]([F:45])([F:20])[F:44])[N:26]=[CH:27]4)[C:16](=[O:18])[N:17]=2)[CH2:12]1)=[O:8]

Participants

3

Reactant 2

HCID 672398093-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl esterHCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 767564023-[(1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

Procedure

3-[(1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester was prepared from 3-{[1-(4-oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester and 1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde following General Procedure D.

Sources & evidence

ORD record
ord-f00074fe79bd4eca95660cc2f602987c
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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