L-Lysine → 7-Amino-2-oxoheptanoic acid

HRID 1950689

Reaction equation

HRID 1950689 reaction equation
[NH2:1][C@H:2](C(O)=O)CCCCN.N[CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[O:20])[C:17]([OH:19])=[O:18]>>[NH2:1][CH2:2][CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[O:20])[C:17]([OH:19])=[O:18]

Participants

3

Reactant 2

HCID 5962L-LysineHCID 4399546-Amino-2-oxohexanoic acid2×

Product 1

HCID 574852297-Amino-2-oxoheptanoic acid

Procedure

In an alternative embodiment, lysine is first converted to 6-amino-2-oxohexanoic acid by an aminotransferase enzyme (EC 2.6.1.x) or a dehydrogenase (EC 1.4.1.x or EC 1.4.3.x). Preferred enzymes are listed in Table 7 and may be engineered to catalyze the desired substrate to product reaction. In a subsequent step, 6-amino-2-oxohexanoic acid is subjected to a carbon elongation enzymatic step to produce 7-amino-2-oxoheptanoic acid.

Workup

  1. customto product reaction

Sources & evidence

ORD record
ord-b8f58644838640a4b61f784a02a4b55e
Source dataset
uspto-grants-2013_03
Patent number
US08404465B2

Linked notes

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