2-Aminocyclohexanone → 2-Methylsulfanyl-N-(2-oxo-cyclohexyl)-4-trifluoromethyl-benzamide

HRID 1950894

Reaction equation

[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].[CH3:9][S:10][C:11]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:12]=1[C:13](O)=[O:14]>>[CH3:9][S:10][C:11]1[CH:19]=[C:18]([C:20]([F:21])([F:22])[F:23])[CH:17]=[CH:16][C:12]=1[C:13]([NH:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8])=[O:14]

Participants

Reactant 2

HCID 4138882-Aminocyclohexanone

HCID 11085762Benzoic acid, 2-(methylthio)-4-(trifluoromethyl)-2×

Product 1

HCID 580629402-Methylsulfanyl-N-(2-oxo-cyclohexyl)-4-trifluoromethyl-benzamide

Procedure

The title compound, off-white solid, MS: m/e=332.1 [(M+H)+], was prepared in accordance with the general method of intermediate B from 2-amino-cyclohexanone and 2-methylsulfanyl-4-trifluoromethyl-benzoic acid (intermediate C).

Sources & evidence

ORD record: ord-e2a32501af0748bdb980d801ccf555f8
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404673B2

Linked notes

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