2-(Trifluoromethyl)benzoic acid → 2-(Methylthio)-6-(trifluoromethyl)benzoic acid

Reaction equation

CO[C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([S:16][CH3:17])[C:4]=1C(O)=O.FC(F)(F)C1C=CC=CC=1[C:22]([OH:24])=[O:23].CSSC>>[CH3:17][S:16][C:8]1[CH:4]=[CH:3][CH:11]=[C:10]([C:12]([F:13])([F:14])[F:15])[C:9]=1[C:22]([OH:24])=[O:23]

Participants

Reactant 3

HCID 98992-(Trifluoromethyl)benzoic acid

HCID 12232Dimethyl Disulfide

HCID 591979212-Methoxy-6-methylsulfanyl-4-trifluoromethyl-benzoic acid

Product 1

HCID 591979032-(Methylthio)-6-(trifluoromethyl)benzoic acid

Procedure

The title compound, white solid, MS: m/e=235.0 [(M−H)−], was prepared in accordance with the general method of intermediate A from 2-(trifluoromethyl)benzoic acid and dimethyl disulfide.

Sources & evidence

ORD record: ord-d319e56e2d4c4f5f8a9449927badb3d7
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08404673B2

Reaction notes

Loading…