2-(5-Ethyloxazol-2-yl)ethylamine → 1-[5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-3-[2-(5-ethyl-oxazol-2-yl)-ethyl]-urea

Reaction equation

CNC(NC1SC(C2C=CN=CC=2)=C(C)N=1)=O.[CH3:18][C:19]1[CH:24]=[C:23]([C:25]2[S:29][C:28]([NH:30][C:31]([N:33]3[CH:37]=[CH:36]N=C3)=[O:32])=[N:27][C:26]=2[CH3:38])[CH:22]=[C:21]([CH3:39])[N:20]=1.[CH2:40]([C:42]1[O:46][C:45](CCN)=[N:44][CH:43]=1)[CH3:41]>>[CH3:39][C:21]1[CH:22]=[C:23]([C:25]2[S:29][C:28]([NH:30][C:31]([NH:33][CH2:37][CH2:36][C:45]3[O:46][C:42]([CH2:40][CH3:41])=[CH:43][N:44]=3)=[O:32])=[N:27][C:26]=2[CH3:38])[CH:24]=[C:19]([CH3:18])[N:20]=1

Participants

Reactant 3

HCID 115428012-(5-Ethyloxazol-2-yl)ethylamine2×

HCID 866103291-Methyl-3-(4-methyl-5-pyridin-4-yl-thiazol-2-yl)-urea

HCID 86610333Imidazole-1-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-amide

Product 1

HCID 114519591-[5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-3-[2-(5-ethyl-oxazol-2-yl)-ethyl]-urea

Procedure

The titled compound is prepared by an analogous procedure to 1-methyl-3-(4-methyl-5-pyridin-4-yl-thiazol-2-yl)-urea (example 18b) by replacing imidazole-1-carboxylic acid (4-methyl-5-pyridin-4-yl-thiazol-2-yl)-amide (example 18a) with imidazole-1-carboxylic acid [5-(2,6-dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]-amide and by replacing methylamine with 2-(5-ethyl-oxazol-2-yl)-ethylamine. The preparation of 2-(5-ethyl-oxazol-2-yl)-ethylamine is described previously.