Formic Acid → 1-(Formylamino)-1H-pyrrole-2-carboxamide
Reaction equation
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:9])=[O:8].[C:10]([O-])(=[O:12])C.[Na+].C(O)=O>>[CH:10]([NH:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:9])=[O:8])=[O:12]Participants
4
Procedure
To a mixture of 1-Amino-1H-pyrrole-2-carboxamide (1.00 g, 8.0 mmol) and sodium acetate (1.60 g, 20.0 mmol) was added formic acid (11.0 ml, 287 mmol). The mixture was stirred overnight at RT. After removing the excess formic acid in vacuo, water (5 mL) was added and the mixture was cooled to 0° C. The mixture was filtered and the solid washed with water and dried in vacuo to afford 1-formamido-1H-pyrrole-2-carboxamide which was advanced without further purification.
Workup
- customAfter removing the excess formic acid in vacuo, water (5 mL)
- additionwas added
- temperaturethe mixture was cooled to 0° C
- filtrationThe mixture was filtered
- washthe solid washed with water
- customdried in vacuo
Sources & evidence
- ORD record
- ord-fbb94cc2f08b4116ad22d3202488767c
- Source dataset
- uspto-grants-2013_03
- Patent number
- US08404694B2
Reaction notes
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