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Triethyl phosphite → HCID 15272444, compound

HRID 1952418
Notes
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Reaction equation

HRID 1952418 reaction equation
[F:1][C:2](Br)([F:14])[C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([F:11])=[C:5]([F:12])[C:4]=1[F:13].[P:16]([O:23]CC)([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19]>O1CCOCC1>[F:1][C:2]([F:14])([P:16](=[O:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19])[C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([F:11])=[C:5]([F:12])[C:4]=1[F:13]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 31215Triethyl phosphiteHCID 218642771-[Bromo(difluoro)methyl]-2,3,4,5,6-pentafluorobenzene

Product 1

HCID 15272444HCID 15272444, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Perfluorobenzyl bromide (2.00 g, 7.66 mmol) and P(OEt)3 (1.66 g, 9.96 mmol) were dissolved in 1,4-dioxane (10 ml) and heated at reflux for 14 hours. Fractional distillation (66-78° C., 60 mm Hg) afforded the product as a colorless oil (2.43 g, 96%)

Workup

  1. temperatureheated
  2. temperatureat reflux for 14 hours
  3. distillationFractional distillation (66-78° C., 60 mm Hg)

Sources & evidence

ORD record
ord-e0e4836cc265494fa478fbe0610d056e
Source dataset
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08405069B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes