Thionyl Chloride → 6-(2-Thienyl)pyridine-3-carbonyl chloride
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=O)=[CH:8][CH:7]=1.S(Cl)([Cl:17])=O>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([Cl:17])=[O:14])=[CH:8][CH:7]=1Participants
3
Procedure
A mixture of 1.8 g of 6-(2-thienyl)pyridine-3-carboxylic acid in 50 ml of thionyl chloride is refluxed under dry conditions for 1 hour. The reaction mixture is evaporated to dryness and evaporated again from 50 ml of carbon tetrachloride to a residue. The residue is dissolved in 60 ml of methylene chloride and used further reactions.
Workup
- temperatureis refluxed under dry conditions for 1 hour
- customThe reaction mixture is evaporated to dryness
- customevaporated again from 50 ml of carbon tetrachloride to a residue
- dissolutionThe residue is dissolved in 60 ml of methylene chloride
Sources & evidence
- ORD record
- ord-f4825270d3b1470cb10e967ab827c960
- Source dataset
- uspto-grants-1998_07
- Patent number
- US05780471
Reaction notes
Loading…