1-Methyl-1H-pyrazole-4-carboxylic acid → N-(2-Fluoroethyl)-N,1-dimethyl-1H-pyrazole-4-carboxamide

Reaction equation

[CH3:1][N:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[CH:4]=[N:3]1.Cl.[F:11][CH2:12][CH2:13][NH:14][CH3:15]>>[F:11][CH2:12][CH2:13][N:14]([CH3:15])[C:7]([C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1)=[O:9]

Participants

Reactant 2

HCID 6431601-Methyl-1H-pyrazole-4-carboxylic acid

HCID 85799809(2-Fluoroethyl)(methyl)amine hydrochloride

Product 1

HCID 58446960N-(2-Fluoroethyl)-N,1-dimethyl-1H-pyrazole-4-carboxamide

Procedure

From 1-methyl-1H-pyrazole-4-carboxylic acid (1.0 g, 7.93 mmol) and 2-fluoro-N-methylethanamine hydrochloride (991 mg, 8.72 mmol). Yellow oil (1.41 g, 92%).

Sources & evidence

ORD record: ord-f947428ab4d64aeeb7ce22a81e8ad4f3
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08410117B2

Reaction notes

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