Thiosemicarbazide → HCID 178527901, compound
Reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[CH:11]=[CH:12]OC)=[CH:4][CH:3]=1.[NH2:17][NH:18][C:19]([NH2:21])=[S:20]>CO>[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:21][C:19](=[S:20])[N:18]3[N:17]=[CH:12][CH:11]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.
Workup
- temperatureis heated
- temperatureto reflux temperature
- filtrationis filtered
- washwashed with methanol
- customThe filtrate with the product is purified by flash silica gel chromatography
Sources & evidence
- ORD record
- ord-1a283ebeecc94dc18563be03e16f73f1
- Source dataset
- uspto-grants-2010_06
- Patent number
- US07745446B2
Reaction notes
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