1-Ethoxypiperidin-4-one → 4-Amino-1-ethoxy-piperidine-4-carbonitrile

HRID 1962362

Reaction equation

HRID 1962362 reaction equation
[NH2:1][C:2]1([C:10]#[N:11])[CH2:7][CH2:6][N:5]([O:8][CH3:9])[CH2:4][CH2:3]1.[CH2:12](ON1CCC(=O)CC1)C>>[NH2:1][C:2]1([C:10]#[N:11])[CH2:3][CH2:4][N:5]([O:8][CH2:9][CH3:12])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 570965291-Ethoxypiperidin-4-oneHCID 596145944-Amino-1-methoxy-piperidine-4-carbonitrile

Product 1

HCID 596146034-Amino-1-ethoxy-piperidine-4-carbonitrile

Procedure

4-Amino-1-ethoxy-piperidine-4-carbonitrile was prepared analogously to the synthesis of 4-amino-1-methoxy-piperidine-4-carbonitrile (preparation example P1, step P1.1) starting from N-ethoxy-4-piperidone (Journal of Organic Chemistry (1961), 26, 1867-74).

Sources & evidence

ORD record
ord-69885318d87c460dbafd2aff2b69e33a
Source dataset
uspto-grants-2013_04
Patent number
US08415369B2

Linked notes

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