Boron tribromide → 4'-[(2-Chlorophenyl)sulfonyl]-3',5-difluorobiphenyl-2-ol
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25]C)[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17])(=[O:10])=[O:9].B(Br)(Br)Br>>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[S:8]([C:7]1[CH:6]=[CH:5][C:4]([C:18]2[C:19]([OH:25])=[CH:20][CH:21]=[C:22]([F:24])[CH:23]=2)=[CH:3][C:2]=1[F:1])(=[O:9])=[O:10]Participants
3
Procedure
The subtitle compound was prepared by the method of example 2 step (iii) using the product of step (iii) and boron tribromide.
Sources & evidence
- ORD record
- ord-8ee5763dc06d4519bdfe5b3699a787d0
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08415394B2
Reaction notes
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