Ethyl 2,2-difluoro-2-phenylacetate → 2,2-Difluoro-2-phenylethanol

Reaction equation

[F:1][C:2]([F:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3](OCC)=[O:4].FC(F)(CCC1C=CC=CC=1)CO>>[F:1][C:2]([F:14])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH2:3][OH:4]

Participants

Reactant 2

HCID 10631860Ethyl 2,2-difluoro-2-phenylacetate

HCID 184257752,2-Difluoro-4-phenylbutan-1-ol

Product 1

HCID 97938912,2-Difluoro-2-phenylethanol

Procedure

Obtained from Intermediate 5 (13.2 g, 66 mmol) by the procedure described in Intermediate 2. The title compound was obtained (6.88 g, 66%) as oil.

Sources & evidence

ORD record: ord-78a3a6239fea41b184544c74c906a751
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08420669B2

Reaction notes

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