4,4-Difluoro-4-phenylbutan-1-ol → {4-[(6-Bromohexyl)oxy]-1,1-difluorobutyl}benzene

Reaction equation

[F:1][C:2]([F:13])([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:3][CH2:4][CH2:5][OH:6].[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]OCC(F)(F)CCC1C=CC=CC=1>>[Br:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][O:6][CH2:5][CH2:4][CH2:3][C:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([F:13])[F:1]

Participants

Reactant 2

HCID 571690084,4-Difluoro-4-phenylbutan-1-ol

HCID 67246468{4-((6-Bromohexyl)oxy]-3,3-difluorobutyl}benzene

Product 1

HCID 67247739{4-[(6-Bromohexyl)oxy]-1,1-difluorobutyl}benzene

Procedure

Obtained from Intermediate 22 (0.6 g, 3.22 mmol) by the procedure described in Intermediate 3. The title compound was obtained (1.98 g, 63% purity) as oil.

Sources & evidence

ORD record: ord-75218ee4fda14e4a973b81f439592a2a
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08420669B2

Reaction notes

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