N-bromobutanimide → Methyl 2-(3-bromo-5-cyano-4-hydroxyphenyl)isonicotinate

HRID 1969133

Reaction equation

HRID 1969133 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:6]=[CH:7][C:8]=1[OH:9])#[N:2].[Br:20]N1C(=O)CCC1=O>C(#N)C>[Br:20][C:7]1[CH:6]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:4]=[C:3]([C:1]#[N:2])[C:8]=1[OH:9]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 136368377Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

Product 1

HCID 136368379Methyl 2-(3-bromo-5-cyano-4-hydroxyphenyl)isonicotinate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate and N-bromosuccinimide were stirred at room temperature in acetonitrile to obtain methyl 2-(3-bromo-5-cyano-4-hydroxyphenyl)isonicotinate. FN: 333.

Sources & evidence

ORD record
ord-57d10c2db03c40d1a530544610651dd3
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Linked notes

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