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2-Dicyclohexylphosphino-2',6'-diisopropoxybiphenyl → HCID 86670326, compound

HRID 1972425
Notes
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Reaction equation

HRID 1972425 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:17])([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.Cl.[CH2:19]([C@@H:21]1[NH:26][CH2:25][CH2:24][N:23]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:22]1)[CH3:20].CC(C)([O-])C.[Na+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC(C)C)=CC=CC=2OC(C)C)CCCCC1>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1>[CH2:19]([C@@H:21]1[N:26]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([OH:17])([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=2)[CH2:25][CH2:24][N:23]([C:27]([O:29][C:30]([CH3:31])([CH3:33])[CH3:32])=[O:28])[CH2:22]1)[CH3:20]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 4

HCID 162179852-Dicyclohexylphosphino-2',6'-diisopropoxybiphenylHCID 232335702-(4-Bromophenyl)-1,1,1,3,3,3-hexafluoropropan-2-olHCID 23676156Sodium t-butoxideHCID 45072247tert-Butyl (3S)-3-ethylpiperazine-1-carboxylate--hydrogen chloride (1/1)

Product 1

HCID 86670326HCID 86670326, compoundYield 103.7%

Reagents, catalysts & solvents 2

HCID 9811564Bis(dibenzylideneacetone)palladiumCatalystHCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.50 g, 1.5 mmol, Bioorg. Med. Chem. Lett. 2002, 12, 3009), tert-butyl (3S)-3-ethyl-1-piperazinecarboxylate hydrochloride (0.40 g, 1.9 mmol, Acesys Pharmatech, North Brunswick, N.J.), sodium tert-butoxide (0.36 g, 3.7 mmol), dicyclohexyl(2′,6′-diisopropoxybiphenyl-2-yl)phosphine (RuPhos) (0.11 g, 0.23 mmol, Strem Chemical Inc, Newburyport, Mass.), tris(dibenzylideneacetone)dipalladium (0) (0.080 g, 0.077 mmol, Strem Chemical Inc, Newburyport, Mass.), and toluene (3.1 mL) were added to a high-pressure reaction vessel. This mixture was sealed and heated at 100° C. for 29 h. After that time, the reaction mixture was allowed to cool to room temperature and then partitioned between EtOAc (25 mL) and saturated aqueous sodium bicarbonate (10 mL). The layers were separated, the organic material was washed sequentially with saturated aqueous sodium bicarbonate (15 mL) and brine (10 mL), dried (Na2SO4), filtered, and concentrated to give tert-butyl (3S)-3-ethyl-4-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl)-1-piperazinecarboxylate (0.71 g) as a brown solid. The material was used in the next step without purification.

Workup

  1. customThis mixture was sealed
  2. temperatureto cool to room temperature
  3. custompartitioned between EtOAc (25 mL) and saturated aqueous sodium bicarbonate (10 mL)
  4. customThe layers were separated
  5. washthe organic material was washed sequentially with saturated aqueous sodium bicarbonate (15 mL) and brine (10 mL)
  6. dry with materialdried (Na2SO4)
  7. filtrationfiltered
  8. concentrationconcentrated

Sources & evidence

ORD record
ord-230804520ba8403bbecd2d5fbab705e8
Source dataset
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08431563B2

Reaction notes

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