Chloroform → HCID 18766188, compound

HRID 19749

Reaction equation

HRID 19749 reaction equation
[NH2:1][O:2][CH2:3][CH:4]([OH:12])[CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.C(Cl)(Cl)Cl.[CH2:17]([N:24]=[C:25]=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>>[OH:12][CH:4]([CH2:5][N:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)[CH2:3][O:2][NH:1][C:25]([NH:24][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:26]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 138341n-Heptyl isocyanateHCID 187662101-(Aminooxy)-3-(piperidin-1-yl)propan-2-ol

Product 1

HCID 18766188HCID 18766188, compound

Procedure

To the solution of 1.23 g (7.1 mmol) of l-aminooxy-2-hydroxy-3-(1-piperidinyl)-propane dissolved in 20 ml of chloroform 1.0 g (7.1 mmol) of heptyl isocyanate was added and the reaction mixture was stirred for 20 hours. Solvent was evaporated in vacuum and the residue was purified by chromatography to give pure colorless oil. White crystalline product was obtained by triturating with petroleum ether.

Workup

  1. additionwas added
  2. customSolvent was evaporated in vacuum
  3. customthe residue was purified by chromatography
  4. customto give pure colorless oil
  5. customWhite crystalline product was obtained
  6. customby triturating with petroleum ether

Sources & evidence

ORD record
ord-5d41a87368eb46de9294345e9b841d10
Source dataset
uspto-grants-2010_06
Patent number
US07745465B2

Linked notes

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