Acetoxyacetyl chloride → 1-[4-(2-Isopropyloxyethyl)aminobenzoyl]-4-[2-(4-chlorophenyl)ethyl]piperazine
Reaction equation
Cl.[CH:2]([O:5][CH2:6][CH2:7][N:8]([C:16]1[CH:38]=[CH:37][C:19]([C:20]([N:22]2[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:24][CH2:23]2)=[O:21])=[CH:18][CH:17]=1)C(=O)COC(=O)C)([CH3:4])[CH3:3].C(OCC(Cl)=O)(=O)C>>[CH:2]([O:5][CH2:6][CH2:7][NH:8][C:16]1[CH:38]=[CH:37][C:19]([C:20]([N:22]2[CH2:23][CH2:24][N:25]([CH2:28][CH2:29][C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:26][CH2:27]2)=[O:21])=[CH:18][CH:17]=1)([CH3:4])[CH3:3]Participants
3
Procedure
In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-acetoxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 130°-132° is obtained from 5 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 21) by reaction with acetoxyacetic acid chloride.