5-Aminoindole → HCID 70241132, compound
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=[CH:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[N:15]=[CH:14][NH:13][C:12]3=O)=[CH:3][CH:2]=1.[NH2:20][C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[NH:26][CH:25]=[CH:24]2>>[NH:26]1[C:27]2[C:23](=[CH:22][C:21]([NH:20][C:12]3[C:11]4[C:16](=[CH:17][CH:18]=[C:9]([CH:8]=[CH:7][C:4]5[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=5)[CH:10]=4)[N:15]=[CH:14][N:13]=3)=[CH:29][CH:28]=2)[CH:24]=[CH:25]1Participants
3
Conditions
- Temperature
- 60 °C
Procedure
The title compound (250 mg, 1.0 mmol) from Example 20 was activated in an analogous method to Example 21 and combined with 5 -aminoindole (171 mg, 1.3 mmol). The reaction mixture was heated at 60° C. overnight and then cooled to room temperature. The resin was filtered off and the solution was concentrated in vacuo. The crude residue was chromatographed on silica gel in 10% acetone/ethyl acetate to provide 270 mg (74%) of the product.