Cyclohexanol → 5-Methyloxepan-2-one

HRID 1976871

Reaction equation

HRID 1976871 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CC1CCC([OH:16])CC1.C1(=O)CCCCC1.C1(O)CCCCC1>>[CH3:1][CH:2]1[CH2:3][CH2:4][O:8][C:5](=[O:16])[CH2:6][CH2:7]1

Participants

5

Reactant 4

HCID 7966CyclohexanolHCID 7967CyclohexanoneHCID 115244-MethylcyclohexanolHCID 115254-Methylcyclohexanone

Product 1

HCID 111160855-Methyloxepan-2-oneYield 45.6%

Procedure

The procedure of Example 25 was repeated, except that 4-methylcyclohexanone (2 mmol) and 4-methylcyclohexanol (20 mmol) were respectively used in stead of cyclohexanone and cyclohexanol. As a result, γ-methyl-ε-caprolactone was formed in yield of 45.6% (on 4-methylcyclohexanone basis).

Sources & evidence

ORD record
ord-e9be06758656493f86556ad392cedec9
Source dataset
uspto-grants-2001_05
Patent number
US06229023B1

Linked notes

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