3-(Cyclopentyloxy)-4-methoxyaniline → 1-Benzyl-4-(3-cyclopentyloxy-4-methoxyanilino)-1,2,5,6-tetrahydropyridin-2-one
Reaction equation
[CH:1]1([O:6][C:7]2[CH:8]=[C:9]([CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[NH2:10])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:16]([N:23]1[CH2:28][CH2:27][C:26](=O)[CH2:25][C:24]1=[O:30])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1C=CC=CC=1>[CH2:16]([N:23]1[CH2:28][CH2:27][C:26]([NH:10][C:9]2[CH:11]=[CH:12][C:13]([O:14][CH3:15])=[C:7]([O:6][CH:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH:8]=2)=[CH:25][C:24]1=[O:30])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1Participants
4
Procedure
0.50 g (2.41 mmole) of 3-cyclopentyloxy-4-methoxyaniline produced in Example 1(2) and 0.49 g (2.41 mmole) of 1-benzyl-2,4-dioxopiperidine were dissolved in 20 ml of benzene and the mixture was stirred at room temperature for 20 hours. After the reaction, the precipitated crystal was collected by filtration and washed with benzene, then was dried in vacuo to obtain the title compound 0.76 g (yield 80.6%) as a light pink solid.