2,3,5-Trifluorobenzyl bromide → 1,2,5-Trifluoro-3-methylbenzene

Reaction equation

Br[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[C:5]([F:10])[C:4]=1[F:11].FC1C=C(C)C=C(F)C=1>>[F:10][C:5]1[CH:6]=[C:7]([F:9])[CH:8]=[C:3]([CH3:2])[C:4]=1[F:11]

Participants

Reactant 2

HCID 27770522,3,5-Trifluorobenzyl bromide

HCID 27783293,5-Difluorotoluene

Product 1

HCID 234469061,2,5-Trifluoro-3-methylbenzene

Procedure

The title compound was prepared from 1-bromomethyl-2,3,5-trifluoro-benzene by a procedure analogous to that for 3,5-difluorotoluene, above. 1H NMR (400 MHz, CDCl3) δ ppm; MS (APCI, m/z): [M+H]+.

Sources & evidence

ORD record: ord-9a11db2986214e49adb33af95f7f3ad2
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235764B1

Reaction notes

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