Hydrochloride methanol → n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978464

Reaction equation

HRID 1978464 reaction equation
[O:1]([CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:32].CO>C(O)C>[ClH:32].[ClH:32].[O:1]([CH2:8][CH2:9][N:10]1[CH2:11][CH2:12][CH:13]([CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:14][CH2:15]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 21993902N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21993901n-[1-(2-Phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 414 mg (0.95 mM) of N-[1-(2-phenoxyethan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (9 ml) was added 1.0 ml (4 mM) of 4N-HCl/methanol and the mixture was stirred at room temperature for 30 minutes. The resulting crystals were collected by filtration and rinsed with ethanol and ether to provide the title compound.

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washrinsed with ethanol and ether

Sources & evidence

ORD record
ord-2ae5c4ed864d4d1690729d5a8fd1e0a6
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Linked notes

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