Water → HCID 178506300, compound

HRID 19785

Reaction equation

HRID 19785 reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[CH:7]=[CH:6][NH:5][N:4]=1.[Cl:10][O-].[Na+].O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[Cl:10][C:7]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:4][NH:5][CH:6]=1

Participants

6

Reactant 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 18070343-(Trifluoromethyl)pyrazoleHCID 23665760Sodium Hypochlorite

Product 1

HCID 178506300HCID 178506300, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of 3-trifluoromethyl-1H-pyrazole (500 mg, 3.67 mmol) in glacial acetic acid (5 ml) was added a 10% solution of sodium hypochlorite in water (2188 μl, 3.67 mmol). The reaction mixture was stirred at RT overnight and then neutralized with sat. sodium carbonate, and extracted with DCM. The organic layers were combined washed with brine, dried (MgSO4), filtered and concentrated in vacuo to give the desired product (480 mg, 77%) as a white solid which did not require further purification. MS (ISP) 169.0 (M−H)−.

Workup

  1. extractionextracted with DCM
  2. washThe organic layers were combined washed with brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-64bade8d2a664b389339781759faacde
Source dataset
uspto-grants-2010_06
Patent number
US07745477B2

Linked notes

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