Formaldehyde → N-methyl-N-tertiarybutylaminoethoxyethanol
Reaction equation
[C:1]([NH:5][CH2:6][CH2:7][O:8][CH:9]([OH:11])[CH3:10])([CH3:4])([CH3:3])[CH3:2].[CH2:12]=O>[Pd].CO>[CH3:12][N:5]([CH2:6][CH2:7][O:8][CH:9]([OH:11])[CH3:10])[C:1]([CH3:4])([CH3:2])[CH3:3]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 80 °C
Procedure
A total of 145 g of tertiarybutylaminoethoxyethanol, 108 g of 37% aqueous formaldehyde, 10 g of 10% Pd/C, and 1 l of methanol were charged to an autoclave, pressured up to 1000 psi with H2 and heated at 80° C. for 8 hours. Filtration and distillation of the reaction mixture yielded 128 g of N-methyl-N-tertiarybutylaminoethoxyethanol with b.p. of 128° C. at 23 mm.
Workup
- filtrationFiltration and distillation of the reaction mixture
Sources & evidence
- ORD record
- ord-85accf3c350941e3b5cc40410d6b155b
- Source dataset
- uspto-grants-1985_04
- Patent number
- US04508692
Reaction notes
Loading…