HCID 54193676, compound → Metyrosine

HRID 1980390Notes

Reaction equation

HRID 1980390 reaction equation
C([NH:11][C@:12]([CH3:24])([C:21]([OH:23])=[O:22])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)(OCC1C=CC=CC=1)=O.[H][H]>[Pd].CO>[CH3:24][C@@:12]([C:21]([OH:23])=[O:22])([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[NH2:11]

Participants

5

Reactant 2

HCID 54193676HCID 54193676, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 441350Metyrosine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

200 milligrams of (S)-N-carbobenzyloxy-α-methyltyrosine is mixed together with 20 milligrams of 10 percent palladium on carbon catalyst and 10 milliliters of methanol and the mixture subjected to hydrogen at a pressure of 40 psi for several hours. Thereafter, the catalyst is removed and the filtrate concentrated to obtain a (S)-α-methyltyrosine product.

Workup

  1. customThereafter, the catalyst is removed
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-dd7c2a77598145819e732c3a835a4e5a
Source dataset
uspto-grants-1985_04
Patent number
US04508921

Reaction notes

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