3-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acid → N-[2-(3-benzyloxy-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide

HRID 19809Notes

Reaction equation

HRID 19809 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:21][CH:20]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:29][C:30]1[C:31]([F:43])=[C:32]([CH:36]=[C:37]([C:39]([F:42])([F:41])[F:40])[CH:38]=1)[C:33](O)=[O:34]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][N:17]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:21][CH:20]=2)[C:33](=[O:34])[C:32]2[CH:36]=[C:37]([C:39]([F:40])([F:41])[F:42])[CH:38]=[C:30]([Cl:29])[C:31]=2[F:43])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27737513-Chloro-2-fluoro-5-(trifluoromethyl)benzoic acidHCID 68562248[2-(3-Benzyloxy-phenyl)-ethyl]-(4-tert-butyl-benzyl)-amine

Product 1

HCID 68562844N-[2-(3-benzyloxy-phenyl)-ethyl]-N-(4-tert-butyl-benzyl)-3-chloro-2-fluoro-5-trifluoromethyl-benzamide

Procedure

The title compound was prepared in analogy to Example 1, using [2-(3-benzyloxy-phenyl)-ethyl]-(4-tert-butyl-benzyl)-amine (S9-C43) and 3-chloro-2-fluoro-5-(trifluoromethyl)benzoic acid. MS: 597.3 [ISP (M+H)+].

Sources & evidence

ORD record
ord-08484c243e8f477eb532cc0ed5a8f40b
Source dataset
uspto-grants-2010_06
Patent number
US07745477B2

Reaction notes

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