1-Propylboronic acid → N-(4-tert-butyl-benzyl)-3-chloro-5-propyl-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide

HRID 19812

Reaction equation

HRID 19812 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:31]=[C:32]([Cl:34])[CH:33]=1)[C:5]([N:7]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([CH3:30])([CH3:29])[CH3:28])=[CH:23][CH:22]=1)[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=1)=[O:6].[CH2:35](B(O)O)[CH2:36][CH3:37]>>[C:27]([C:24]1[CH:25]=[CH:26][C:21]([CH2:20][N:7]([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[C:5](=[O:6])[C:4]2[CH:3]=[C:2]([CH2:35][CH2:36][CH3:37])[CH:33]=[C:32]([Cl:34])[CH:31]=2)=[CH:22][CH:23]=1)([CH3:29])([CH3:28])[CH3:30]

Participants

3

Reactant 2

HCID 3510651-Propylboronic acidHCID 685616143-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide

Product 1

HCID 68559834N-(4-tert-butyl-benzyl)-3-chloro-5-propyl-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide

Procedure

The title compound was prepared in analogy to example 3, using 3-bromo-N-(4-tert-butyl-benzyl)-5-chloro-N-[2-(3-trifluoromethyl-phenyl)-ethyl]-benzamide (Example B176) and n-propylboronic acid. 516.2 [ISP (M+H)+]

Sources & evidence

ORD record
ord-9bb4ecb6e2ca42ea91dd9b2ee2c3f691
Source dataset
uspto-grants-2010_06
Patent number
US07745477B2

Linked notes

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