Methyl 2-(1-benzylpyrrolidin-3-yl)acetate → Methyl 2-(pyrrolidin-3-yl)acetate
Reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:9]1)C1C=CC=CC=1>[Pd].C(O)C>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:9]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The above prepared methyl 1-benzyl-3-pyrrolidineacetate hexamate was reduced in three portions, using 3.9 g. of 10% palladium on carbon in 200 ml. of absolute ethanol, for one hour at 50° C. The reaction mixture was filtered and concentrated to give methyl 3-pyrrolidineacetate hexamate, m.p. 68.5°-69.5° C.
Workup
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-602380c5ea2d4a12abe6184b0d009ee8
- Source dataset
- uspto-grants-1985_04
- Patent number
- US04514414
Reaction notes
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