Ammonia → 4-Hydroxy-3-methoxy-benzamidine
Reaction equation
[NH3:1].Cl.CO[N:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1>CO>[C:6]([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([O:14][CH3:15])[CH:8]=1)(=[NH:5])[NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a mixture of 100 ml of anhydrous methanol and about 50 ml of liquid ammonia, was added slowly 8.7 g of 4-methoxyiminomethyl-2-methoxyphenol hydrochloride. The mixture was stirred overnight at room temperature. The colorless crystals precipitated from the reaction mixture were collected by filtration, washed thoroughly with methanol, and dried to obtain 7.4 g of 4-amidino-2-methoxyphenol.
Workup
- customThe colorless crystals precipitated from the reaction mixture
- filtrationwere collected by filtration
- washwashed thoroughly with methanol
- customdried
Sources & evidence
- ORD record
- ord-9fde3508b3b4405e96ad8ca2694bb74a
- Source dataset
- uspto-grants-1985_04
- Patent number
- US04514416
Reaction notes
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