3-Hydroxy-2,2-dimethylpropionic acid → HCID 23317293, compound

Reaction equation

[OH:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([OH:6])=O.[NH2:9][CH:10]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:11]([O:13][CH2:14][CH3:15])=[O:12]>>[OH:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([NH:9][CH:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[O:6]

Participants

Reactant 2

HCID 785483-Hydroxy-2,2-dimethylpropionic acid

HCID 81272Propanedioic acid, 2-amino-, 1,3-diethyl ester

Product 1

HCID 23317293HCID 23317293, compoundYield 88%

Procedure

Diethyl N(β-hydroxypivaloyl)aminomalonate was prepared (method B) from β-hydroxy pivalic acid and diethyl aminomalonate in 88% yield. The compound was isolated as an oil. NMR 1.13-1.3 (12H, m), 3.5 (2H, br s), 4.16-4.4 (4H, q), 5.1-5.16 (1H, d), 7.6-7.7 (1H, d).

Workup

customThe compound was isolated as an oil

Sources & evidence

ORD record: ord-62626761337d4321b67e59f8c2686ff7
Source dataset: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04595532

Reaction notes

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