Acetic Anhydride → HCID 13651755, compound
Reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([N:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:13][N:14]([CH3:24])[C:15]1[CH:23]=[CH:22][C:18](C(O)=O)=[CH:17][CH:16]=1.[C:25](OC(=O)C)(=[O:27])C>>[Cl:1][C:2]1[CH:9]=[C:8]([N:10]([CH3:12])[CH3:11])[CH:7]=[CH:6][C:3]=1[CH:4]1[C:18]2[C:22](=[CH:23][C:15]([N:14]([CH3:13])[CH3:24])=[CH:16][CH:17]=2)[C:25](=[O:27])[O:5]1Participants
4
Procedure
Following a procedure similar to that described above in Example 1, part A, 36.6 g of 2-chloro-4-dimethylaminobenzaldehyde and 33.0 g of 4-dimethylaminobenzoic acid were interacted in acetic anhydride to obtain 52.1 g of 3-(2-chloro-4-dimethylaminophenyl)-6-dimethylaminophthalide (Formula I: R=CH3 ; X=Z=H; Y=2-Cl-4-(CH3)2NC6H3) as a red crystalline solid which melted at 159°-160° C.