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Thionyl Chloride → HCID 23149124, compound

HRID 1983022
Notes
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Reaction equation

HRID 1983022 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7]O)[CH:6]=1.S(Cl)([Cl:11])=O>ClCCl>[ClH:11].[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:7][Cl:11])[CH:6]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19614660(4-bromo-1H-pyrazol-1-yl)methanol

Product 1

HCID 23149124HCID 23149124, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.97 g of 4-bromo-1H-pyrazole-1-ylmethanol was dissolved to 100ml of dichloromethane. 5 ml of thionyl chloride was added to the solution, followed by stirring at room temperature for overnight. The reaction mixture was concentrated under reduced pressure to obtain 3.27 g of 4-bromo-1-(chloromethyl)-1H-pyrazole hydrochloride.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7938914136d04ebb89959247bfe93a59
Source dataset
uspto-grants-2009_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07541374B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes