Sodium Hydroxide → HCID 178506331, compound

Temperature

0 °C

9.30 g of 3-(pentafluoroethyl)-1H-pyrazole was suspended to 90 ml of water, and 6.0 g of 50% aqueous solution of sodium hydroxide was added to the suspension. The mixture was cooled to 0° C., then 8.79 g of bromine was added to the mixture, followed by stirring at room temperature for 7 hours. The reaction mixture was extracted by ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium salfate, filtered, and concentrated under reduced pressure to obtain 13.72 g of 4-bromo-3-(pentafluoroethyl)-1H-pyrazole.

1. additionwas added to the suspension
2. extractionThe reaction mixture was extracted by ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialdried over anhydrous magnesium salfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure

ORD record

ord-c6db249ae75c4745986a803d2a414c46

Source dataset

uspto-grants-2009_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07541374B2