Formaldehyde → 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol
Reaction equation
[F:1][C:2]([F:9])([F:8])[C:3]1[N:4]=[CH:5][NH:6][CH:7]=1.[CH2:10]=[O:11]>CC(C)=O>[F:1][C:2]([F:9])([F:8])[C:3]1[N:4]=[CH:5][N:6]([CH2:10][OH:11])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 140 °C
Procedure
The mixture of 1.80 g of 4-(trifluoromethyl)-1H-imidazole, 0.78 g of paraformaldehyde was stirred at 140° C. for 4 hours. After the reaction mixture was cooled to room temperature, acetone was added. The mixture was filtered, and then the filtrate was concentrated under reduced pressure to obtain 2.16 g of 4-(trifluoromethyl)-1H-imidazole-1-ylmethanol.
Workup
- temperatureAfter the reaction mixture was cooled to room temperature
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-54bcd229106b40e9a7dfced4cd582c5d
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07541374B2
Reaction notes
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