HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1984635Generated: October 23, 2026
1-(2-(Dimethylamino)ethyl)piperazine → HCID 57713955, compound
https://huagongshe.com/en/reaction/1984635
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(2-(Dimethylamino)ethyl)piperazine | HCID 2736229 | — |
| Reactant | 4-[2-(Ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde | HCID 57713940 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57713955 | HCID 57713955 | — |
Reaction Steps
To a solution of 4-[2-(ethylsulfinyl)-6-phenylpyrido[2,3-d]pyrimidin-7-yl]benzaldehyde (6-4; 900 mg, 2.33 mmoles) in dioxane (1 mL) was added 1-(2-dimethylaminoethyl)-piperazine (66 mg, 2.33 mmoles) and heated to 150° C. in a microwave reactor for 30 min. The mixture was concentrated under reduced pressure and the residue was purified by silica gel chromatography (100% Hex. to 100% EtOAc) to give the title compound. LRMS m/z (M+H) Calcd: 467.2, found 467.6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07544677B2 |
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| Source dataset | uspto-grants-2009_06 |
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| ORD ID | ord-2f506c1a8a194f31a3b5d65708e32791 |
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| Source note | uspto-grants-2009_06 |
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