HCID 10863545, compound → HCID 11021339, compound

Reaction equation

[C:1]([O:5][C:6]([C:8]1([CH3:32])[CH2:12][O:11][S:10](=[O:14])(=[O:13])[N:9]1[CH:15](C1C=CC(OC)=CC=1)C1C=CC(OC)=CC=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OC(C1(C)COS(=O)N1C)=O)(C)(C)C>>[C:1]([O:5][C:6]([C:8]1([CH3:32])[CH2:12][O:11][S:10](=[O:13])(=[O:14])[N:9]1[CH3:15])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 10863545HCID 10863545, compound

HCID 11031843HCID 11031843, compound

Product 1

HCID 11021339HCID 11021339, compoundYield 94%

Procedure

The same reaction conditions used to obtain 14a were applied to 42 mg of 13b (0.18 mmol), providing 14b (42 mg, 94%) as a white solid: mp 54-55° C. (EtOAc/hexane); 1H NMR (CDCl3) δ1.50 (9H, s), 1.52 (3H, s), 2.93 (3H, s), 4.22 (1H, d, J=8.8), 4.88 (1H, d, J=8.8). Anal (C9H17NO5S)C,H,N.

Workup

customThe same reaction conditions

Sources & evidence

ORD record: ord-25c3c1eced7b42babebe670f5b6fcafa
Source dataset: uspto-grants-2009_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07544715B2

Reaction notes

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