(5-Fluoromethylpyridin-2-yl)methanol → 5-(Fluoromethyl)picolinaldehyde
Reaction equation
[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][OH:10])=[N:7][CH:8]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[F:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[N:7][CH:8]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Manganese dioxide (1.4 g) is added in a single portion to a solution of compound (5) (0.3 g) in chloroform (5 ml) at room temperature. The suspension is stirred vigorously for 7 hours and then diluted with chloroform and filtered through Celite. The filtrate is concentrated under vacuum and the yellow oil obtained (0.25 g) is used in its present form in the following reductive amination step.
Workup
- filtrationfiltered through Celite
- concentrationThe filtrate is concentrated under vacuum
- customthe yellow oil obtained (0.25 g)
Sources & evidence
- ORD record
- ord-b9294ab3250e4e2887e69d869f8f68e4
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07547700B2
Reaction notes
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