Fludarabine Phosphate → Fludarabine phosphate magnesium salt

HRID 1986019

Reaction equation

HRID 1986019 reaction equation
[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][O:16][P:17]([OH:20])([OH:19])=[O:18])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[O-2].[Mg+2:26]>O>[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:21])[C@@H:11]2[OH:22])[C:8]2[C:3](=[C:4]([NH2:24])[N:5]=[C:6]([F:23])[N:7]=2)[N:2]=1.[Mg+2:26].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[P:17]([O-:20])([O-:19])([O-:18])=[O:16].[Mg+2:26].[Mg+2:26]

Participants

4

Reactant 2

HCID 30751Fludarabine PhosphateHCID 6850729Magnesium monoxide

Product 1

HCID 86755286Fludarabine phosphate magnesium saltYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

10.0 g of fludarabine phosphate at a purity of 97.5% is suspended in 100 ml of water within about 5 minutes, and magnesium oxide is added to this solution. The mixture is stirred for one more hour at room temperature and then filtered. The clear solution is poured into 200 ml of acetone, stirred for 1 more hour, and the crystallizate is separated by filtration. 10.0 g (95% of theory) of the fludarabine-phosphate magnesium salt is obtained.

Workup

  1. filtrationfiltered
  2. additionThe clear solution is poured into 200 ml of acetone
  3. stirringstirred for 1 more hour
  4. customthe crystallizate is separated by filtration

Sources & evidence

ORD record
ord-d21ed0f6c92449e488827afdcd927451
Source dataset
uspto-grants-2009_06
Patent number
US07547776B1

Linked notes

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