1-(3-Aminopropyl)-4-methylpiperazine → HCID 68856220, compound

HRID 1986253

Reaction equation

HRID 1986253 reaction equation
[ClH:1].Cl.Cl.S1C(C2C=CN=C([NH:15][CH2:16][CH2:17][CH2:18][N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)N=2)=CC2C=CC=CC1=2.[Br:30][C:31]1[CH:32]=[CH:33][C:34]2[CH:38]=[C:37]([C:39]3[C:44]([CH3:45])=[CH:43][N:42]=[C:41]([Cl:46])[N:40]=3)[S:36][C:35]=2[CH:47]=1.NCCCN1CCN(C)CC1>>[ClH:46].[ClH:1].[ClH:46].[Br:30][C:31]1[CH:32]=[CH:33][C:34]2[CH:38]=[C:37]([C:39]3[C:44]([CH3:45])=[CH:43][N:42]=[C:41]([NH:15][CH2:16][CH2:17][CH2:18][N:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)[N:40]=3)[S:36][C:35]=2[CH:47]=1

Participants

4

Reactant 3

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 68855962HCID 68855962, compoundHCID 866253744-(6-Bromobenzo[b]thiophen-2-yl)-2-chloro-5-methylpyrimidine

Product 1

HCID 68856220HCID 68856220, compound

Procedure

Using the method of [4-(benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-[3-(4-methylpiperazin-1-yl)-propyl]-amine tri-hydrochloride, the title compound is prepared from 4-(6-bromobenzo[b]thiophen-2-yl)-2-chloro-5-methylpyrimidine and 1-(3-aminopropyl)-4-methylpiperazine and isolated as a solid. ES+(m/z) 460 (79Br) and 462 (81Br) [M+H].

Workup

  1. customisolated as a solid

Sources & evidence

ORD record
ord-38ea2aa0a86446e19db7680f5c3a5637
Source dataset
uspto-grants-2009_06
Patent number
US07547691B2

Linked notes

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