3-Isobutyl-1-methylxanthine → N7-bromoehtyl 3-isobutyl-1-methylxanthine

HRID 1986606

Reaction equation

HRID 1986606 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][NH:10][C:9]=2[C:8](=[O:14])[N:7]([CH3:15])[C:6]1=[O:16])[CH:2]([CH3:4])[CH3:3].[Br:17][CH2:18][CH2:19]N.[OH-].[Na+]>CO>[Br:17][CH2:18][CH2:19][N:10]1[C:9]2[C:8](=[O:14])[N:7]([CH3:15])[C:6](=[O:16])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[C:13]=2[N:12]=[CH:11]1

Participants

5

Reactant 3

HCID 37583-Isobutyl-1-methylxanthineHCID 78512-BromoethylamineHCID 14798Sodium Hydroxide

Product 1

HCID 69056164N7-bromoehtyl 3-isobutyl-1-methylxanthine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The process of preparing the compound of formula I comprises the steps of dissolving 3-isobutyl-1-methylxanthine (IBMX) into methanol and stirring with 2-bromoethylamine upon a mantle heater, reacting this mixture with NaOH and then recrystallizing this mixture with methanol to obtain N7-bromoehtyl 3-isobutyl-1-methylxanthine.

Workup

  1. customThe process of preparing the compound of formula I
  2. customrecrystallizing this mixture with methanol

Sources & evidence

ORD record
ord-2844dad69a4b4a888264a6e4aab7ae9d
Source dataset
uspto-grants-2009_06
Patent number
US07550468B2

Linked notes

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