HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichlorobenzeneboronic acid → [1-(3,4-Dichloro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichlorobenzeneboronic acid | HCID 2734330 | — |
| Reactant | (5-(1-isopropylpiperidin-4-yloxy)-1H-indol-2-yl)(morpholino)methanone | HCID 11717680 | — |
| Product | [1-(3,4-Dichloro-phenyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone | HCID 16739560 | — |
Reaction Steps
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from [5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-morpholin-4-yl-methanone (intermediate 2) and 3,4-dichlorobenzeneboronic acid. The title compound was obtained in 90% yield as yellow foam. MS (m/e): 516.2 (MH+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745479B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e8f122d670ac4fb685b43d68348e826d |
| Source note | uspto-grants-2010_06 |