4-(4-Chlorophenyl)-1H-pyrrole-2-carboxylic acid → HCID 67214733, compound
Reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][C:9]([CH3:12])([OH:11])[CH3:10])=[C:4]([O:15][CH3:16])[CH:3]=1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([C:29](O)=[O:30])[NH:27][CH:28]=2)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:25]=[C:26]([C:29]([NH:1][C:2]3[CH:14]=[CH:13][C:5]([O:6][CH2:7][CH2:8][C:9]([OH:11])([CH3:12])[CH3:10])=[C:4]([O:15][CH3:16])[CH:3]=3)=[O:30])[NH:27][CH:28]=2)=[CH:20][CH:19]=1Participants
3
Procedure
Acylation of 4-(4-amino-2-methoxyphenoxy)-2-methylbutan-2-ol from step A with 4-(4-chlorophenyl)-1H-pyrrole-2-carboxylic acid to generate the title compound was achieved via the procedure described in step C of Example 1. The crude product was used for next step without further purification.
Sources & evidence
- ORD record
- ord-6afda45b3e394bcfaa88d6bde1aa8240
- Source dataset
- uspto-grants-2009_06