Ethanol → 4-(4-Methoxyphenyl)-1-(2H)-phthalazinone
Reaction equation
[NH2:1][NH2:2].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=2[C:13](O)=O)=[CH:7][CH:6]=1.[CH2:20]([OH:22])C>>[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:19]3[C:13](=[CH:12][CH:16]=[CH:17][CH:18]=3)[C:20](=[O:22])[NH:2][N:1]=2)=[CH:9][CH:10]=1Participants
4
Conditions
- Temperature
- 60 °C
Procedure
4.10 ml (81.2 mmol) of hydrazine was added to an ethanol solution (100 ml) of 17.33 g (67.6 mmol) of the obtained 2-(4-methoxyphenyl)-benzoic acid, and the reaction liquid was stirred at 60° C. for 4 hours. The reaction liquid was concentrated under reduced pressure, and the resulting solid was washed with diethyl ether to obtain 9.46 g (yield: 55%) of 4-(4-methoxyphenyl)-2H-phthalazin-1-on as a white solid.