Isopropylamine → 2-Chloro-4-fluoro-5-[(isopropylamino)sulfonyl]benzoic acid

HRID 1992139Notes

Reaction equation

HRID 1992139 reaction equation
ClS(C1C=C(C=CC=1F)C(O)=O)(=O)=O.[CH:15]([NH2:18])([CH3:17])[CH3:16].[Cl:19][C:20]1[CH:28]=[C:27]([F:29])[C:26]([S:30](NCC)(=[O:32])=[O:31])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23]>>[Cl:19][C:20]1[CH:28]=[C:27]([F:29])[C:26]([S:30]([NH:18][CH:15]([CH3:17])[CH3:16])(=[O:32])=[O:31])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 39298913-(Chlorosulfonyl)-4-fluorobenzoic acidHCID 587280522-Chloro-5-[(ethylamino)sulfonyl]-4-fluorobenzoic acid

Product 1

HCID 587286562-Chloro-4-fluoro-5-[(isopropylamino)sulfonyl]benzoic acid

Procedure

1.002 g (3.6 mmol) 3-chlorosulfonyl-4-fluorobenzoic acid was added to 0.94 mL (10.9 mmol) isopropylamine following the general procedure in for 2-chloro-5-[(ethylamino)sulfonyl]-4-fluorobenzoic acid. Crude product was used in subsequent step without further purification

Workup

  1. customCrude product was used in subsequent step without further purification

Sources & evidence

ORD record
ord-7c6c22f29f2f4b848cc36ba4e4c756c9
Source dataset
uspto-grants-2010_01
Patent number
US07645771B2

Reaction notes

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